What is Glibenclamide
Glibenclamide is an antidiabetic drug used to treat Type 2 diabetes. It is also known as Glyburide. People with Type 2 diabetes or non-insulin dependent diabetes mellitus (NIDDM) has a common deficiency in producing a hormone known as insulin by the pancreas (pancreas is an insulin producing organ right beneath our stomach). Glibenclamide helps to raise the nervous activity in the pancreas biological system, in order to produce more insulin to control the blood glucose level in our blood stream.
Glibenclamide acts by interacting with Potassium channels on the pancreas’s beta cells, stimulating the channels to open up and releasing the Potassium ions, it then depolarizes the membrane, allowing Calsium ions to get into the pathway and agitates the secretory granules which contains insulin, to release the insulin into the blood stream.
When to take Glibenclamide
Glibenclamide is to be taken orally, before morning breakfast. If your breakfast intake is light, then take the medicine before lunch. It can be taken together with other diabetes medicine. It works well along a controlled diet which is sugarless and less starchy food.
It is important to control the blood glucose level, if it is not control properly, you may experience low blood glucose (hypoglycaemia) level or high blood glucose level (hyperglycaemia). Glucose meter is used to determine if a person is experiencing hypo- or hyperglycaemia. For hypoglycaemia, the glucose meter reading is 2-3 mmol/L, while for hyperglycaemia, the glucose meter reading is > 11 mmol/L.
Symptoms of low blood glucose level :
• Dizziness (the feeling of your surrounding is spinning)
• Frequent sweating
• Feeling depress at time
• Difficulty to sleep through the night
• Feeling hungry
Symptoms of high blood glucose level :
• Feeling tired and unenergetic
• Feeling thirsty very often
• Frequent urination
• Genital itching
• Slow healing of wound
• Blurred vision
• Weight loss
As diabetes is related to the inefficiency of insulin to allow glucose to be absorbed into the cells, further worsen for people categorized under Type 2 diabetes, in which the pancreas is worn out to function properly to release insulin by itself, there is no cure for diabetes. Diabetes can only be controlled through the use of antidiabetic medicine. As this is may be life long battle, it is advisable to control your diet as well. Some food for thought as below :
• High fiber whole grains like oatmeal
• Fish like Salmon
• Beans which provides high quality carbohydrate
• Fat free yogurt
• Almond nuts
• Non-starchy vegetables
While there is no direct relation taking fruits with high-sugar content raises the blood sugar level, it is advisable to choose those fruits with low-sugar content, like lime, raspberry or avocado.
There are various dosages of Glibenclamide on the pharmacy’s shelf, in 1.5mg, 2.5mg and 5mg tablet form. You should consult your doctor on the dosage per day, dependent on your blood glucose level.